Oliceridine in the treatment of moderate to severe acute pain.

Journal Article (Journal Article;Review)

Intravenous opioids are a mainstay for the management of moderate to severe acute pain. Opioid administration provides effective pain control at the cost of significant side effects. Commonly used opioids like morphine are nonselective μ-receptor agonists, which stimulate both the G-protein pathway, associated with the analgesic effect, and the β-arrestin pathway, associated with the side effects. Oliceridine is a G-protein selective ligand at the μ-receptor with less activation of the β-arrestin pathway. The drug has recently been US FDA approved. This review will focus on the efficacy and safety of intravenous oliceridine in the treatment of moderate to severe acute pain.

Full Text

Duke Authors

Cited Authors

  • Eleswarpu, SS; Habib, AS

Published Date

  • May 1, 2021

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 237 - 248

PubMed ID

  • 33455450

Electronic International Standard Serial Number (EISSN)

  • 1758-1877

Digital Object Identifier (DOI)

  • 10.2217/pmt-2020-0087


  • eng

Conference Location

  • England