Cardiorespiratory coupling is associated with exercise capacity in patients with chronic obstructive pulmonary disease.

Journal Article (Journal Article)

Background

The interaction between the pulmonary function and cardiovascular mechanics is a crucial issue, particularly when treating patients with chronic obstructive pulmonary disease (COPD). Synchrogram index is a new parameter that can quantify this interaction and has the potential to apply in COPD patients. Our objective in this study was to characterize cardiorespiratory interactions in terms of cardiorespiratory coupling (CRC) using the synchrogram index of the heart rate and respiratory flow signals in patients with chronic obstructive pulmonary disease.

Methods

This is a cross-sectional and preliminary data from a prospective study, which examines 55 COPD patients. K-means clustering analysis was applied to cluster COPD patients based on the synchrogram index. Linear regression and multivariable regression analysis were used to determine the correlation between the synchrogram index and the exercise capacity assessed by a six-minute walking test (6MWT).

Results

The 55 COPD patients were separated into a synchronized group (median 0.89 (0.64-0.97), n = 43) and a desynchronized group (median 0.23 (0.02-0.51), n = 12) based on K-means clustering analysis. Synchrogram index was correlated significantly with six minutes walking distance (r = 0.42, p = 0.001) and distance saturation product (r = 0.41, p = 0.001) assessed by 6MWT, and still was an independent variable by multivariable regression analysis.

Conclusion

This is the first result studying the heart-lung interaction in terms of cardiorespiratory coupling in COPD patients by the synchrogram index, and COPD patients are clustered into synchronized and desynchronized groups. Cardiorespiratory coupling is associated with exercise capacity in patients with COPD.

Full Text

Duke Authors

Cited Authors

  • Huang, Y-C; Lin, T-Y; Wu, H-T; Chang, P-J; Lo, C-Y; Wang, T-Y; Kuo, C-HS; Lin, S-M; Chung, F-T; Lin, H-C; Hsieh, M-H; Lo, Y-L

Published Date

  • January 12, 2021

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 22 -

PubMed ID

  • 33435937

Pubmed Central ID

  • PMC7802271

Electronic International Standard Serial Number (EISSN)

  • 1471-2466

International Standard Serial Number (ISSN)

  • 1471-2466

Digital Object Identifier (DOI)

  • 10.1186/s12890-021-01400-1

Language

  • eng