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Protective plant immune responses are elicited by bacterial outer membrane vesicles.

Publication ,  Journal Article
McMillan, HM; Zebell, SG; Ristaino, JB; Dong, X; Kuehn, MJ
Published in: Cell Rep
January 19, 2021

Bacterial outer membrane vesicles (OMVs) perform a variety of functions in bacterial survival and virulence. In mammalian systems, OMVs activate immune responses and are exploited as vaccines. However, little work has focused on the interactions of OMVs with plant hosts. Here, we report that OMVs from Pseudomonas syringae and P. fluorescens activate plant immune responses that protect against bacterial and oomycete pathogens. OMV-mediated immunomodulatory activity from these species displayed different sensitivity to biochemical stressors, reflecting differences in OMV content. Importantly, OMV-mediated plant responses are distinct from those triggered by conserved bacterial epitopes or effector molecules alone. Our study shows that OMV-induced protective immune responses are independent of the T3SS and protein, but that OMV-mediated seedling growth inhibition largely depends on proteinaceous components. OMVs provide a unique opportunity to understand the interplay between virulence and host response strategies and add a new dimension to consider in host-microbe interactions.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

January 19, 2021

Volume

34

Issue

3

Start / End Page

108645

Location

United States

Related Subject Headings

  • Plant Immunity
  • Immunity
  • Bacterial Outer Membrane Proteins
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

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McMillan, H. M., Zebell, S. G., Ristaino, J. B., Dong, X., & Kuehn, M. J. (2021). Protective plant immune responses are elicited by bacterial outer membrane vesicles. Cell Rep, 34(3), 108645. https://doi.org/10.1016/j.celrep.2020.108645
McMillan, Hannah M., Sophia G. Zebell, Jean B. Ristaino, Xinnian Dong, and Meta J. Kuehn. “Protective plant immune responses are elicited by bacterial outer membrane vesicles.Cell Rep 34, no. 3 (January 19, 2021): 108645. https://doi.org/10.1016/j.celrep.2020.108645.
McMillan HM, Zebell SG, Ristaino JB, Dong X, Kuehn MJ. Protective plant immune responses are elicited by bacterial outer membrane vesicles. Cell Rep. 2021 Jan 19;34(3):108645.
McMillan, Hannah M., et al. “Protective plant immune responses are elicited by bacterial outer membrane vesicles.Cell Rep, vol. 34, no. 3, Jan. 2021, p. 108645. Pubmed, doi:10.1016/j.celrep.2020.108645.
McMillan HM, Zebell SG, Ristaino JB, Dong X, Kuehn MJ. Protective plant immune responses are elicited by bacterial outer membrane vesicles. Cell Rep. 2021 Jan 19;34(3):108645.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

January 19, 2021

Volume

34

Issue

3

Start / End Page

108645

Location

United States

Related Subject Headings

  • Plant Immunity
  • Immunity
  • Bacterial Outer Membrane Proteins
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology