Janus kinase inhibitors for atopic dermatitis: a promising treatment modality.

Journal Article (Journal Article;Review)

Atopic dermatitis (AD) is chronic, pruritic, inflammatory skin disease that affects a significant portion of the population in industrialized nations. For nonresponders to conventional therapies, AD can significantly reduce sleep quality and quality of life. AD pathogenesis is multifactorial and involves multiple immune pathways, with recent evidence of T helper (Th)2, Th17 and Th22 axis attenuation in various AD endotypes and racial subtypes. Inhibition of the conserved Janus kinase (JAK) signalling pathway represents a promising therapeutic avenue to reduce the activation of multiple proinflammatory mediators involved in AD pathogenesis. JAK inhibitors exist in both oral and topical forms with variable specificity for the receptor tyrosine kinases JAK1, JAK2, JAK3 and tyrosine kinase 2. Oral formulations include abrocitinib, upadacitinib, baricitinib and gusacitinib, and are most appropriate for patients with moderate to severe AD. Emerging topical formulation in development include ruxolitinib and deglocitinib, which may be used in patients with localized AD and also adjunctively with systemic therapy in patients with more severe disease. With observed rapidity in itch relief and accompanying dramatic reduction in inflammatory lesion count, JAK inhibitors represent a promising new treatment to revolutionize the management of AD.

Full Text

Duke Authors

Cited Authors

  • Cartron, AM; Nguyen, TH; Roh, YS; Kwatra, MM; Kwatra, SG

Published Date

  • July 2021

Published In

Volume / Issue

  • 46 / 5

Start / End Page

  • 820 - 824

PubMed ID

  • 33484582

Electronic International Standard Serial Number (EISSN)

  • 1365-2230

Digital Object Identifier (DOI)

  • 10.1111/ced.14567


  • eng

Conference Location

  • England