Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices.

Journal Article (Journal Article)

Acoustics-based tweezers provide a unique toolset for contactless, label-free, and precise manipulation of bioparticles and bioanalytes. Most acoustic tweezers rely on acoustic radiation forces; however, the accompanying acoustic streaming often generates unpredictable effects due to its nonlinear nature and high sensitivity to the three-dimensional boundary conditions. Here, we demonstrate acoustohydrodynamic tweezers, which generate stable, symmetric pairs of vortices to create hydrodynamic traps for object manipulation. These stable vortices enable predictable control of a flow field, which translates into controlled motion of droplets or particles on the operating surface. We built a programmable droplet-handling platform to demonstrate the basic functions of planar-omnidirectional droplet transport, merging droplets, and in situ mixing via a sequential cascade of biochemical reactions. Our acoustohydrodynamic tweezers enables improved control of acoustic streaming and demonstrates a previously unidentified method for contact-free manipulation of bioanalytes and digitalized liquid handling based on a compact and scalable functional unit.

Full Text

Duke Authors

Cited Authors

  • Zhu, H; Zhang, P; Zhong, Z; Xia, J; Rich, J; Mai, J; Su, X; Tian, Z; Bachman, H; Rufo, J; Gu, Y; Kang, P; Chakrabarty, K; Witelski, TP; Huang, TJ

Published Date

  • January 6, 2021

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • eabc7885 -

PubMed ID

  • 33523965

Pubmed Central ID

  • PMC7787489

Electronic International Standard Serial Number (EISSN)

  • 2375-2548

International Standard Serial Number (ISSN)

  • 2375-2548

Digital Object Identifier (DOI)

  • 10.1126/sciadv.abc7885

Language

  • eng