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Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer.

Publication ,  Journal Article
Yin, F; Xie, H; Lai, J; Chen, Y; Dong, J; Zhang, X; Liu, X
Published in: Anticancer Res
October 2020

BACKGROUND: Patients with inflammatory bowel disease have markedly increased risk for developing colitis-associated colorectal adenocarcinoma (CAC). There is no established prognostic biomarker for CAC. MATERIALS AND METHODS: A retrospective study was performed on a cohort of 57 CACs. Expression of caudal type homeobox transcription factor 2 (CDX2) and YES-associated protein 1 (YAP1) expression was correlated with clinicodemographic and histopathological features. RESULTS: Neither YAP1 nor CDX2 expression alone was significantly associated with tumor invasion beyond the muscularis propria or lymph node status. However, a subgroup of CAC with double negativity for expression of YAP1 and CDX2 was more frequently found in younger patients, and more frequently associated with higher pathological tumor stage and nodal metastasis. Furthermore, a positive correlation between CDX2 and YAP1 expression was identified in CAC and sporadic colorectal adenocarcinoma. CONCLUSION: Our study demonstrates that double negativity for expression of YAP1 and CDX2 defines a subgroup of CAC with early onset and aggressive clinical features.

Duke Scholars

Published In

Anticancer Res

DOI

EISSN

1791-7530

Publication Date

October 2020

Volume

40

Issue

10

Start / End Page

5411 / 5416

Location

Greece

Related Subject Headings

  • YAP-Signaling Proteins
  • Transcription Factors
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Inflammatory Bowel Diseases
  • Humans
  • Female
  • Colorectal Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yin, F., Xie, H., Lai, J., Chen, Y., Dong, J., Zhang, X., & Liu, X. (2020). Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer. Anticancer Res, 40(10), 5411–5416. https://doi.org/10.21873/anticanres.14550
Yin, Feng, Hao Xie, Jinping Lai, Yuanhong Chen, Jixin Dong, Xuefeng Zhang, and Xiuli Liu. “Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer.Anticancer Res 40, no. 10 (October 2020): 5411–16. https://doi.org/10.21873/anticanres.14550.
Yin F, Xie H, Lai J, Chen Y, Dong J, Zhang X, et al. Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer. Anticancer Res. 2020 Oct;40(10):5411–6.
Yin, Feng, et al. “Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer.Anticancer Res, vol. 40, no. 10, Oct. 2020, pp. 5411–16. Pubmed, doi:10.21873/anticanres.14550.
Yin F, Xie H, Lai J, Chen Y, Dong J, Zhang X, Liu X. Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer. Anticancer Res. 2020 Oct;40(10):5411–5416.

Published In

Anticancer Res

DOI

EISSN

1791-7530

Publication Date

October 2020

Volume

40

Issue

10

Start / End Page

5411 / 5416

Location

Greece

Related Subject Headings

  • YAP-Signaling Proteins
  • Transcription Factors
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Inflammatory Bowel Diseases
  • Humans
  • Female
  • Colorectal Neoplasms