Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.

Journal Article (Journal Article)

Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known "pro-aging" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.

Full Text

Duke Authors

Cited Authors

  • Bareja, A; Draper, JA; Katz, LH; Lee, DE; Grimsrud, PA; White, JP

Published Date

  • April 2021

Published In

Volume / Issue

  • 195 /

Start / End Page

  • 111443 -

PubMed ID

  • 33529682

Pubmed Central ID

  • PMC8035222

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2021.111443


  • eng

Conference Location

  • Ireland