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An objective structural and functional reference standard in glaucoma.

Publication ,  Journal Article
Mariottoni, EB; Jammal, AA; Berchuck, SI; Shigueoka, LS; Tavares, IM; Medeiros, FA
Published in: Sci Rep
January 18, 2021

The current lack of consensus for diagnosing glaucoma makes it difficult to develop diagnostic tests derived from deep learning (DL) algorithms. In the present study, we propose an objective definition of glaucomatous optic neuropathy (GON) using clearly defined parameters from optical coherence tomography and standard automated perimetry. We then use the proposed objective definition as reference standard to develop a DL algorithm to detect GON on fundus photos. A DL algorithm was trained to detect GON on fundus photos, using the proposed objective definition as reference standard. The performance was evaluated on an independent test sample with sensitivity, specificity, area under the receiver operating characteristic curve (AUC), and likelihood ratios (LR). The test sample had 2118 fundus photos from 585 eyes of 405 individuals. The AUC to discriminate between GON and normal was 0.92 with sensitivity of 77% at 95% specificity. LRs indicated that the DL algorithm provided large changes in the post-test probability of disease for the majority of eyes. A DL algorithm to evaluate fundus photos had high performance to discriminate GON from normal. The newly proposed objective definition of GON used as reference standard may increase the comparability of diagnostic studies of glaucoma across devices and populations.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 18, 2021

Volume

11

Issue

1

Start / End Page

1752

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Reference Standards
  • ROC Curve
  • Photography
  • Optic Nerve Diseases
  • Middle Aged
  • Male
  • Humans
  • Glaucoma
  • Fundus Oculi
 

Citation

APA
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ICMJE
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Mariottoni, E. B., Jammal, A. A., Berchuck, S. I., Shigueoka, L. S., Tavares, I. M., & Medeiros, F. A. (2021). An objective structural and functional reference standard in glaucoma. Sci Rep, 11(1), 1752. https://doi.org/10.1038/s41598-021-80993-3
Mariottoni, Eduardo B., Alessandro A. Jammal, Samuel I. Berchuck, Leonardo S. Shigueoka, Ivan M. Tavares, and Felipe A. Medeiros. “An objective structural and functional reference standard in glaucoma.Sci Rep 11, no. 1 (January 18, 2021): 1752. https://doi.org/10.1038/s41598-021-80993-3.
Mariottoni EB, Jammal AA, Berchuck SI, Shigueoka LS, Tavares IM, Medeiros FA. An objective structural and functional reference standard in glaucoma. Sci Rep. 2021 Jan 18;11(1):1752.
Mariottoni, Eduardo B., et al. “An objective structural and functional reference standard in glaucoma.Sci Rep, vol. 11, no. 1, Jan. 2021, p. 1752. Pubmed, doi:10.1038/s41598-021-80993-3.
Mariottoni EB, Jammal AA, Berchuck SI, Shigueoka LS, Tavares IM, Medeiros FA. An objective structural and functional reference standard in glaucoma. Sci Rep. 2021 Jan 18;11(1):1752.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 18, 2021

Volume

11

Issue

1

Start / End Page

1752

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Reference Standards
  • ROC Curve
  • Photography
  • Optic Nerve Diseases
  • Middle Aged
  • Male
  • Humans
  • Glaucoma
  • Fundus Oculi