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Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study.

Publication ,  Journal Article
Khan, N; Lindner, S; Gomes, ALC; Devlin, SM; Shah, GL; Sung, AD; Sauter, CS; Landau, HJ; Dahi, PB; Perales, M-A; Chung, DJ; Lesokhin, AM ...
Published in: Blood
March 18, 2021

We previously described clinically relevant reductions in fecal microbiota diversity in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). Recipients of high-dose chemotherapy and autologous HCT (auto-HCT) incur similar antibiotic exposures and nutritional alterations. To characterize the fecal microbiota in the auto-HCT population, we analyzed 1161 fecal samples collected from 534 adult recipients of auto-HCT for lymphoma, myeloma, and amyloidosis in an observational study conducted at 2 transplantation centers in the United States. By using 16S ribosomal gene sequencing, we assessed fecal microbiota composition and diversity, as measured by the inverse Simpson index. At both centers, the diversity of early pretransplant fecal microbiota was lower in patients than in healthy controls and decreased further during the course of transplantation. Loss of diversity and domination by specific bacterial taxa occurred during auto-HCT in patterns similar to those with allo-HCT. Above-median fecal intestinal diversity in the periengraftment period was associated with decreased risk of death or progression (progression-free survival hazard ratio, 0.46; 95% confidence interval, 0.26-0.82; P = .008), adjusting for disease and disease status. This suggests that further investigation into the health of the intestinal microbiota in auto-HCT patients and posttransplant outcomes should be undertaken.

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

March 18, 2021

Volume

137

Issue

11

Start / End Page

1527 / 1537

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Gastrointestinal Microbiome
  • Female
  • Feces
  • Aged
 

Citation

APA
Chicago
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MLA
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Khan, N., Lindner, S., Gomes, A. L. C., Devlin, S. M., Shah, G. L., Sung, A. D., … Peled, J. U. (2021). Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. Blood, 137(11), 1527–1537. https://doi.org/10.1182/blood.2020006923
Khan, Niloufer, Sarah Lindner, Antonio L. C. Gomes, Sean M. Devlin, Gunjan L. Shah, Anthony D. Sung, Craig S. Sauter, et al. “Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study.Blood 137, no. 11 (March 18, 2021): 1527–37. https://doi.org/10.1182/blood.2020006923.
Khan N, Lindner S, Gomes ALC, Devlin SM, Shah GL, Sung AD, et al. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. Blood. 2021 Mar 18;137(11):1527–37.
Khan, Niloufer, et al. “Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study.Blood, vol. 137, no. 11, Mar. 2021, pp. 1527–37. Pubmed, doi:10.1182/blood.2020006923.
Khan N, Lindner S, Gomes ALC, Devlin SM, Shah GL, Sung AD, Sauter CS, Landau HJ, Dahi PB, Perales M-A, Chung DJ, Lesokhin AM, Dai A, Clurman A, Slingerland JB, Slingerland AE, Brereton DG, Giardina PA, Maloy M, Armijo GK, Rondon-Clavo C, Fontana E, Bohannon L, Ramalingam S, Bush AT, Lew MV, Messina JA, Littmann E, Taur Y, Jenq RR, Chao NJ, Giralt S, Markey KA, Pamer EG, van den Brink MRM, Peled JU. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. Blood. 2021 Mar 18;137(11):1527–1537.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

March 18, 2021

Volume

137

Issue

11

Start / End Page

1527 / 1537

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Gastrointestinal Microbiome
  • Female
  • Feces
  • Aged