Biological Aspects of Cancer Health Disparities.


Racial and ethnic disparities span the continuum of cancer care and are driven by a complex interplay among social, psychosocial, lifestyle, environmental, health system, and biological determinants of health. Research is needed to identify these determinants of cancer health disparities and to develop interventions to achieve cancer health equity. Herein, we focus on the overall burden of ancestry-related molecular alterations, the functional significance of the alterations in hallmarks of cancer, and the implications of the alterations for precision oncology and immuno-oncology. In conclusion, we reflect on the importance of estimating ancestry, improving diverse racial and ethnic participation in cancer clinical trials, and examining the intersection among determinants of cancer health disparities.

Full Text

Duke Authors

Cited Authors

  • Freedman, JA; Al Abo, M; Allen, TA; Piwarski, SA; Wegermann, K; Patierno, SR

Published Date

  • January 27, 2021

Volume / Issue

  • 72 /

Start / End Page

  • 229 - 241

PubMed ID

  • 33502900

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-070119-120305