Fueling Cell Invasion through Extracellular Matrix.
Cell invasion through extracellular matrix (ECM) has pivotal roles in cell dispersal during development, immune cell trafficking, and cancer metastasis. Many elegant studies have revealed the specialized cellular protrusions, proteases, and distinct modes of migration invasive cells use to overcome ECM barriers. Less clear, however, is how invasive cells provide energy, specifically ATP, to power the energetically demanding membrane trafficking, F-actin polymerization, and actomyosin machinery that mediate break down, remodeling, and movement through ECMs. Here, we provide an overview of the challenges of examining ATP generation and delivery within invading cells and how recent studies using diverse invasion models, experimental approaches, and energy biosensors are revealing that energy metabolism is an integral component of cell invasive behavior that is dynamically tuned to overcome the ECM environment.
Duke Scholars
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Related Subject Headings
- Extracellular Matrix
- Developmental Biology
- Cell Movement
- Actomyosin
- Actins
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Extracellular Matrix
- Developmental Biology
- Cell Movement
- Actomyosin
- Actins
- 3101 Biochemistry and cell biology
- 11 Medical and Health Sciences
- 06 Biological Sciences