Fueling Cell Invasion through Extracellular Matrix.

Journal Article (Review;Journal Article)

Cell invasion through extracellular matrix (ECM) has pivotal roles in cell dispersal during development, immune cell trafficking, and cancer metastasis. Many elegant studies have revealed the specialized cellular protrusions, proteases, and distinct modes of migration invasive cells use to overcome ECM barriers. Less clear, however, is how invasive cells provide energy, specifically ATP, to power the energetically demanding membrane trafficking, F-actin polymerization, and actomyosin machinery that mediate break down, remodeling, and movement through ECMs. Here, we provide an overview of the challenges of examining ATP generation and delivery within invading cells and how recent studies using diverse invasion models, experimental approaches, and energy biosensors are revealing that energy metabolism is an integral component of cell invasive behavior that is dynamically tuned to overcome the ECM environment.

Full Text

Duke Authors

Cited Authors

  • Garde, A; Sherwood, DR

Published Date

  • June 2021

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 445 - 456

PubMed ID

  • 33549396

Pubmed Central ID

  • PMC8122022

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2021.01.006


  • eng