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Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy.

Publication ,  Journal Article
St John, AL; Choi, HW; Walker, QD; Blough, B; Kuhn, CM; Abraham, SN; Staats, HF
Published in: NPJ Vaccines
February 5, 2020

Cocaine is one of the most potent and addictive psychostimulants known and there are no available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine vaccine employing the mucosal adjuvant and mast cell-activating oligopeptide, mastoparan-7 (M7), to achieve optimal IgA antibody responses in mucosal secretions and effective induction of humoral immunity using a short immunization protocol. This formulation, using a hapten-carrier system to deliver cocaine as antigen, also reduced cocaine penetration of the blood brain barrier and protected mice from its psychoactive effects by reducing cocaine-induced locomotion. Surprisingly, the magnitude of cocaine-specific antibody titers induced by each adjuvant was not the major determinant of functional protection from cocaine challenge. A side-by-side comparison of the two haptens, cocaine and its analog GNC demonstrated that cocaine haptenation resulted in superior functional protection when used in combination with the novel mucosal adjuvant, M7. These results provide a new potential strategy for combatting cocaine addiction through mucosal vaccination.

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Published In

NPJ Vaccines

DOI

EISSN

2059-0105

Publication Date

February 5, 2020

Volume

5

Issue

1

Start / End Page

12

Location

England

Related Subject Headings

  • 3207 Medical microbiology
  • 3204 Immunology
 

Citation

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St John, A. L., Choi, H. W., Walker, Q. D., Blough, B., Kuhn, C. M., Abraham, S. N., & Staats, H. F. (2020). Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. NPJ Vaccines, 5(1), 12. https://doi.org/10.1038/s41541-020-0161-1
St John, Ashley L., Hae Woong Choi, Q David Walker, Bruce Blough, Cynthia M. Kuhn, Soman N. Abraham, and Herman F. Staats. “Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy.NPJ Vaccines 5, no. 1 (February 5, 2020): 12. https://doi.org/10.1038/s41541-020-0161-1.
St John AL, Choi HW, Walker QD, Blough B, Kuhn CM, Abraham SN, et al. Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. NPJ Vaccines. 2020 Feb 5;5(1):12.
St John, Ashley L., et al. “Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy.NPJ Vaccines, vol. 5, no. 1, Feb. 2020, p. 12. Pubmed, doi:10.1038/s41541-020-0161-1.
St John AL, Choi HW, Walker QD, Blough B, Kuhn CM, Abraham SN, Staats HF. Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. NPJ Vaccines. 2020 Feb 5;5(1):12.

Published In

NPJ Vaccines

DOI

EISSN

2059-0105

Publication Date

February 5, 2020

Volume

5

Issue

1

Start / End Page

12

Location

England

Related Subject Headings

  • 3207 Medical microbiology
  • 3204 Immunology