Targeting MET Amplification with Crizotinib in a Case of Sinonasal Undifferentiated Carcinoma.

Journal Article (Journal Article)

Comprehensive molecular testing of individual tumors has led to the identification of novel molecularly defined cancer therapies and treatment indications. Given low frequencies of many molecular alterations, efficacy of therapies used to target them are often undefined, especially in the context of rare malignancies. Here we describe the first reported case of MET amplification in sinonasal undifferentiated carcinoma (SNUC), a rare cancer with a poor prognosis. The patient was treated with crizotinib, a tyrosine kinase inhibitor that targets c-MET, and experienced a complete response. Our report demonstrates the potential of employing precision oncology approaches in SNUC and other rare cancers.

Full Text

Duke Authors

Cited Authors

  • Robinson, H; Green, M; Radkar, G; Ready, N; Strickler, J

Published Date

  • March 2021

Published In

Volume / Issue

  • 39 / 3

Start / End Page

  • 235 - 239

PubMed ID

  • 33538211

Electronic International Standard Serial Number (EISSN)

  • 1532-4192

Digital Object Identifier (DOI)

  • 10.1080/07357907.2021.1884695


  • eng

Conference Location

  • England