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The Roles of T cells in Bladder Pathologies.

Publication ,  Journal Article
Wu, J; Abraham, SN
Published in: Trends Immunol
March 2021

T lymphocytes play important roles in the skin and mucosal surfaces such as the gut and lung. Until recently the contributions of T cells to mammalian bladder immunity were largely unknown. With newer techniques, including single-cell RNA sequencing and reporter mice, an understanding is emerging of T cell roles in bladder diseases (bacterial infections, bladder cancer, chronic inflammation). In these pathologies, many bladder T cell responses can be harmful to the host through suboptimal clearance of bacteria or cancer cells, or by modulating autoinflammation. Recent findings suggest that T cell behavior might be influenced by resident T cell interactions with the bladder microbiota and other immunostimulants. Thus, regulating bladder T cell functions could emerge as a putative immunotherapy to treat some bladder diseases.

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Published In

Trends Immunol

DOI

EISSN

1471-4981

Publication Date

March 2021

Volume

42

Issue

3

Start / End Page

248 / 260

Location

England

Related Subject Headings

  • Urinary Bladder
  • T-Lymphocytes
  • Mucous Membrane
  • Microbiota
  • Mice
  • Immunology
  • Bacteria
  • Animals
  • 3204 Immunology
  • 3101 Biochemistry and cell biology
 

Citation

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Wu, J., & Abraham, S. N. (2021). The Roles of T cells in Bladder Pathologies. Trends Immunol, 42(3), 248–260. https://doi.org/10.1016/j.it.2021.01.003
Wu, Jianxuan, and Soman N. Abraham. “The Roles of T cells in Bladder Pathologies.Trends Immunol 42, no. 3 (March 2021): 248–60. https://doi.org/10.1016/j.it.2021.01.003.
Wu J, Abraham SN. The Roles of T cells in Bladder Pathologies. Trends Immunol. 2021 Mar;42(3):248–60.
Wu, Jianxuan, and Soman N. Abraham. “The Roles of T cells in Bladder Pathologies.Trends Immunol, vol. 42, no. 3, Mar. 2021, pp. 248–60. Pubmed, doi:10.1016/j.it.2021.01.003.
Wu J, Abraham SN. The Roles of T cells in Bladder Pathologies. Trends Immunol. 2021 Mar;42(3):248–260.
Journal cover image

Published In

Trends Immunol

DOI

EISSN

1471-4981

Publication Date

March 2021

Volume

42

Issue

3

Start / End Page

248 / 260

Location

England

Related Subject Headings

  • Urinary Bladder
  • T-Lymphocytes
  • Mucous Membrane
  • Microbiota
  • Mice
  • Immunology
  • Bacteria
  • Animals
  • 3204 Immunology
  • 3101 Biochemistry and cell biology