The Roles of T cells in Bladder Pathologies.

Journal Article (Journal Article;Review)

T lymphocytes play important roles in the skin and mucosal surfaces such as the gut and lung. Until recently the contributions of T cells to mammalian bladder immunity were largely unknown. With newer techniques, including single-cell RNA sequencing and reporter mice, an understanding is emerging of T cell roles in bladder diseases (bacterial infections, bladder cancer, chronic inflammation). In these pathologies, many bladder T cell responses can be harmful to the host through suboptimal clearance of bacteria or cancer cells, or by modulating autoinflammation. Recent findings suggest that T cell behavior might be influenced by resident T cell interactions with the bladder microbiota and other immunostimulants. Thus, regulating bladder T cell functions could emerge as a putative immunotherapy to treat some bladder diseases.

Full Text

Duke Authors

Cited Authors

  • Wu, J; Abraham, SN

Published Date

  • March 2021

Published In

Volume / Issue

  • 42 / 3

Start / End Page

  • 248 - 260

PubMed ID

  • 33536141

Pubmed Central ID

  • PMC7914211

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

Digital Object Identifier (DOI)

  • 10.1016/j.it.2021.01.003

Language

  • eng

Conference Location

  • England