The Roles of T cells in Bladder Pathologies.
Journal Article (Journal Article;Review)
T lymphocytes play important roles in the skin and mucosal surfaces such as the gut and lung. Until recently the contributions of T cells to mammalian bladder immunity were largely unknown. With newer techniques, including single-cell RNA sequencing and reporter mice, an understanding is emerging of T cell roles in bladder diseases (bacterial infections, bladder cancer, chronic inflammation). In these pathologies, many bladder T cell responses can be harmful to the host through suboptimal clearance of bacteria or cancer cells, or by modulating autoinflammation. Recent findings suggest that T cell behavior might be influenced by resident T cell interactions with the bladder microbiota and other immunostimulants. Thus, regulating bladder T cell functions could emerge as a putative immunotherapy to treat some bladder diseases.
Full Text
Duke Authors
Cited Authors
- Wu, J; Abraham, SN
Published Date
- March 2021
Published In
Volume / Issue
- 42 / 3
Start / End Page
- 248 - 260
PubMed ID
- 33536141
Pubmed Central ID
- PMC7914211
Electronic International Standard Serial Number (EISSN)
- 1471-4981
Digital Object Identifier (DOI)
- 10.1016/j.it.2021.01.003
Language
- eng
Conference Location
- England