Advances in the Diagnosis and Management of Neonatal Sarcomas.
Neonatal sarcomas comprise a heterogeneous group of rare soft tissue neoplasms that present unique diagnostic and therapeutic challenges. Recent advances in molecular profiling have improved diagnostic capabilities and reveal novel therapeutic targets. Clinical trials demonstrate differences in behavior between sarcoma subtypes that allow for better clinical management. Surgical resection has been replaced with a multimodal approach that includes chemotherapy and radiotherapy. Despite these advances, neonates with sarcoma continue to fare worse than histologically similar sarcomas in older children, likely reflecting differences in tumor biology and the complexities of neonatal medicine. This review focuses on recent advances in managing neonatal sarcomas.
Duke Scholars
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Related Subject Headings
- Soft Tissue Neoplasms
- Sarcoma
- Rhabdomyosarcoma
- Pediatrics
- Infant, Newborn
- Humans
- Child
- 3215 Reproductive medicine
- 3213 Paediatrics
- 1114 Paediatrics and Reproductive Medicine
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Soft Tissue Neoplasms
- Sarcoma
- Rhabdomyosarcoma
- Pediatrics
- Infant, Newborn
- Humans
- Child
- 3215 Reproductive medicine
- 3213 Paediatrics
- 1114 Paediatrics and Reproductive Medicine