Advances in the Diagnosis and Management of Neonatal Sarcomas.

Journal Article (Journal Article;Review)

Neonatal sarcomas comprise a heterogeneous group of rare soft tissue neoplasms that present unique diagnostic and therapeutic challenges. Recent advances in molecular profiling have improved diagnostic capabilities and reveal novel therapeutic targets. Clinical trials demonstrate differences in behavior between sarcoma subtypes that allow for better clinical management. Surgical resection has been replaced with a multimodal approach that includes chemotherapy and radiotherapy. Despite these advances, neonates with sarcoma continue to fare worse than histologically similar sarcomas in older children, likely reflecting differences in tumor biology and the complexities of neonatal medicine. This review focuses on recent advances in managing neonatal sarcomas.

Full Text

Duke Authors

Cited Authors

  • Rashid, T; Noyd, DH; Iranzad, N; Davis, JT; Deel, MD

Published Date

  • March 2021

Published In

Volume / Issue

  • 48 / 1

Start / End Page

  • 117 - 145

PubMed ID

  • 33583500

Electronic International Standard Serial Number (EISSN)

  • 1557-9840

Digital Object Identifier (DOI)

  • 10.1016/j.clp.2020.11.007


  • eng

Conference Location

  • United States