Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure.

Journal Article (Journal Article;Multicenter Study)

We examined the relationship between pain severity and outcomes in patients with heart failure with reduced ejection fraction (HFrEF) in the HF-ACTION randomized controlled trial. Trends of health-related quality of life (HRQoL) measures grouped by patients' self-reported baseline bodily pain severity were compared using correlation tests, and the association between pain severity and clinical outcomes (including a primary composite endpoint of all-cause mortality and all-cause hospitalization) was assessed using multivariable adjusted analyses. Of the 2310 patients, 22.9% reported no pain, 45.8% very mild/mild, 24.9% moderate, and 6.4% severe/very severe. Greater pain severity was associated with worse HRQoL measures (EuroQoL-5D-3L and Kansas City Cardiomyopathy Questionnaire; both p < 0.0001). Compared to those reporting no pain, patients reporting severe/very severe pain had greater risk for the primary endpoint (adjusted hazard ratio 1.42, 95% confidence interval 1.11-1.83, p = 0.01). In patients with HFrEF, greater pain severity was associated with worse HRQoL and clinical outcomes. Trial Registration: NCT00047437.

Full Text

Duke Authors

Cited Authors

  • Feng, KY; O'Connor, CM; Clare, R; Alhanti, B; Piña, IL; Kraus, WE; Whellan, DJ; Mentz, RJ

Published Date

  • October 2021

Published In

Volume / Issue

  • 14 / 5

Start / End Page

  • 984 - 991

PubMed ID

  • 33564986

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-021-10104-0

Language

  • eng

Conference Location

  • United States