Therapeutic Approaches for the No-Option Refractory Angina Patient.

Journal Article (Journal Article;Review)

The combination of an aging population and improved survival rates among patients with coronary artery disease has resulted in an increase in the number of patients with refractory angina or anginal equivalent symptoms despite maximal medical therapy. Patients with refractory angina are often referred to the cardiac catheterization laboratory; however, they have often exhausted conventional revascularization options; thus, this population is often deemed as having "no options." We review the definition, prevalence, outcomes, therapeutic options, and treatment considerations for no-option refractory angina patients and focus on novel therapies for this complex and challenging population. We propose a multidisciplinary team approach for the evaluation and management of patients with refractory angina, ideally in a designated clinic. The severe limitations and symptomatology experienced by these patients highlight the need for additional research into the development of innovative treatments.

Full Text

Duke Authors

Cited Authors

  • Povsic, TJ; Henry, TD; Ohman, EM

Published Date

  • February 2021

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • e009002 -

PubMed ID

  • 33541098

Electronic International Standard Serial Number (EISSN)

  • 1941-7632

Digital Object Identifier (DOI)

  • 10.1161/CIRCINTERVENTIONS.120.009002


  • eng

Conference Location

  • United States