Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.

Journal Article

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.

Full Text

Duke Authors

Cited Authors

  • Narayanasamy, S; Nation, RL; Mahony, AA; Grayson, ML; Kwong, JC; Sherry, NL; Khumra, S; Ellis, AG; Frauman, AG; Holmes, NE

Published Date

  • January 2021

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • ofaa572 -

PubMed ID

  • 33511225

Pubmed Central ID

  • PMC7817083

Electronic International Standard Serial Number (EISSN)

  • 2328-8957

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofaa572


  • eng