Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.

Journal Article

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.

Full Text

Duke Authors

Narayanasamy, Shanti

Cited Authors

Narayanasamy, S; Nation, RL; Mahony, AA; Grayson, ML; Kwong, JC; Sherry, NL; Khumra, S; Ellis, AG; Frauman, AG; Holmes, NE

Published Date

January 2021

Published In

Open Forum Infectious Diseases

Volume / Issue

8 / 1

Start / End Page

ofaa572 -

PubMed ID

33511225

Pubmed Central ID

PMC7817083

Electronic International Standard Serial Number (EISSN)

2328-8957

International Standard Serial Number (ISSN)

2328-8957

Digital Object Identifier (DOI)

10.1093/ofid/ofaa572

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