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Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis.

Publication ,  Journal Article
Liddle, RA
Published in: J Clin Invest
February 1, 2021

Due to progressive inflammation, chronic pancreatitis destroys both the exocrine and endocrine pancreas and sensitizes pancreatic nerves, leading to unremitting pain. Unfortunately, there are no treatments for pancreatic inflammation and approaches to ameliorate pain are suboptimal. Pancreatic inflammation is particularly problematic because damage to acinar cells causes local release of digestive enzymes, which initiate pancreatic autodigestion. The combination of autodigestion and inflammation is unique to pancreatitis and undoubtedly contributes to the difficulty in devising effective treatments. In this issue of the JCI, Saleh et al. describe a nonsurgical technique to ablate pancreatic acinar cells, thus eliminating the source of digestive enzymes and preventing autodigestion. In mice and a nonhuman primate model, this approach effectively reduced inflammation and pain while preserving islet cell function. These findings support the concept that ongoing acinar cell damage is at the root of chronic pancreatitis and provide a possible strategy for clinical treatment.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

February 1, 2021

Volume

131

Issue

3

Location

United States

Related Subject Headings

  • Pancreatitis
  • Pancreatectomy
  • Pancreas, Exocrine
  • Pancreas
  • Mice
  • Immunology
  • Animals
  • Acinar Cells
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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ICMJE
MLA
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Liddle, R. A. (2021). Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis. J Clin Invest, 131(3). https://doi.org/10.1172/JCI146210
Liddle, Rodger A. “Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis.J Clin Invest 131, no. 3 (February 1, 2021). https://doi.org/10.1172/JCI146210.
Liddle, Rodger A. “Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis.J Clin Invest, vol. 131, no. 3, Feb. 2021. Pubmed, doi:10.1172/JCI146210.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

February 1, 2021

Volume

131

Issue

3

Location

United States

Related Subject Headings

  • Pancreatitis
  • Pancreatectomy
  • Pancreas, Exocrine
  • Pancreas
  • Mice
  • Immunology
  • Animals
  • Acinar Cells
  • 42 Health sciences
  • 32 Biomedical and clinical sciences