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Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway.

Publication ,  Journal Article
Bisnett, BJ; Condon, BM; Lamb, CH; Georgiou, GR; Boyce, M
Published in: Front Cell Dev Biol
2020

The coat protein complex II (COPII) mediates forward trafficking of protein and lipid cargoes from the endoplasmic reticulum. COPII is an ancient and essential pathway in all eukaryotes and COPII dysfunction underlies a range of human diseases. Despite this broad significance, major aspects of COPII trafficking remain incompletely understood. For example, while the biochemical features of COPII vesicle formation are relatively well characterized, much less is known about how the COPII system dynamically adjusts its activity to changing physiologic cues or stresses. Recently, post-transcriptional mechanisms have emerged as a major mode of COPII regulation. Here, we review the current literature on how post-transcriptional events, and especially post-translational modifications, govern the COPII pathway.

Duke Scholars

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Published In

Front Cell Dev Biol

DOI

ISSN

2296-634X

Publication Date

2020

Volume

8

Start / End Page

618652

Location

Switzerland

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Bisnett, B. J., Condon, B. M., Lamb, C. H., Georgiou, G. R., & Boyce, M. (2020). Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway. Front Cell Dev Biol, 8, 618652. https://doi.org/10.3389/fcell.2020.618652
Bisnett, Brittany J., Brett M. Condon, Caitlin H. Lamb, George R. Georgiou, and Michael Boyce. “Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway.Front Cell Dev Biol 8 (2020): 618652. https://doi.org/10.3389/fcell.2020.618652.
Bisnett BJ, Condon BM, Lamb CH, Georgiou GR, Boyce M. Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway. Front Cell Dev Biol. 2020;8:618652.
Bisnett, Brittany J., et al. “Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway.Front Cell Dev Biol, vol. 8, 2020, p. 618652. Pubmed, doi:10.3389/fcell.2020.618652.
Bisnett BJ, Condon BM, Lamb CH, Georgiou GR, Boyce M. Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway. Front Cell Dev Biol. 2020;8:618652.

Published In

Front Cell Dev Biol

DOI

ISSN

2296-634X

Publication Date

2020

Volume

8

Start / End Page

618652

Location

Switzerland

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 31 Biological sciences