Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques.
Journal Article (Journal Article)
Despite incredible scientific efforts, there is no cure for HIV infection. While antiretroviral treatment (ART) can help control the virus and prevent transmission, it cannot eradicate HIV from viral reservoirs established before the initiation of therapy. Further, HIV-infected individuals reliably exhibit viral rebound when ART is interrupted, suggesting that the host immune response fails to control viral replication in persistent reservoirs. Therapeutic vaccines are one current approach to improving antiviral host immune responses and enhance long term virus control. In the present study, we used an integrase defective lentiviral vector (IDLV) expressing SIV-Gag to boost anti-Gag specific immune responses in macaques chronically infected with the tier-2 SHIV-1157(QNE)Y173H. A single immunization with IDLV-SIV-Gag induced durable (>20 weeks) virus control in 55% of the vaccinated macaques, correlating with an increased magnitude of SIV-Gag specific CD8+ T-cell responses. IDLV-based therapeutic vaccines are therefore an effective approach to improve virus specific CD8+ T-cell responses and mediate virus control.
Full Text
Duke Authors
Cited Authors
- Blasi, M; Wescott, EC; Baker, EJ; Mildenberg, B; LaBranche, C; Rountree, W; Haynes, BF; Saunders, KO; Moody, MA; Negri, D; Santra, S; Cara, A; Klotman, ME
Published Date
- May 8, 2020
Published In
Volume / Issue
- 5 / 1
Start / End Page
- 36 -
PubMed ID
- 33580065
Pubmed Central ID
- 33580065
Electronic International Standard Serial Number (EISSN)
- 2059-0105
Digital Object Identifier (DOI)
- 10.1038/s41541-020-0186-5
Language
- eng
Conference Location
- England