BK virus nephropathy in non-renal solid organ transplant recipients: Are we looking hard enough?

Journal Article (Journal Article)

We retrospectively examined the clinical characteristics, pathological features, and outcomes of BK viremia and nephropathy in a population of non-renal solid organ transplant patients (NRSOT) referred for outpatient nephrology consultation over a period of 5 years. In the entire cohort of liver, heart, and lung transplant recipients referred to this clinic, 14% percent were found to have BK viremia with a median peak serum BK viral load of 35 500 copies/ml (range 250 to 21 100 000 copies/ml). BK viremia resolved in six of the seventeen patients (35%). Four out of five patients biopsied showed BK virus (BKV) nephropathy. Eleven out of seventeen patients with BK viremia developed advanced (stage 4 or 5) chronic kidney disease. Four patients developed rejection of their solid organ transplant within the first year post detection of BK viremia after immunosuppression reduction. We conclude that a multi-center study is required to evaluate whether implementation of a systematic BK screening program would be effective in early detection and management of this problem in the NRSOT population.

Full Text

Duke Authors

Cited Authors

  • Mallavarapu, RK; Sanoff, SL; Howell, DN; Roberts, JK

Published Date

  • May 1, 2021

Published In

Volume / Issue

  • 35 / 5

Start / End Page

  • e14265 -

PubMed ID

  • 33615555

Electronic International Standard Serial Number (EISSN)

  • 1399-0012

Digital Object Identifier (DOI)

  • 10.1111/ctr.14265


  • eng

Conference Location

  • Denmark