The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.
Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic metabolism and appetite, leptin displays pleiotropic actions, and it is now clear that leptin has a key role in influencing immune cell function. Indeed, many immune cells have been shown to respond to leptin directly via the leptin receptor, resulting in a largely pro-inflammatory phenotype. Understanding the role of adipose-tissue derived mediators in inflammation is critical to determining the pathophysiology of multiple obesity-associated diseases, such as type 2 diabetes, autoimmune disease, and infection. This review, therefore, focuses on the latest data regarding the role of leptin in modulating inflammation.
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Related Subject Headings
- Receptors, Leptin
- Obesity
- Leptin
- Infections
- Humans
- Diabetes Mellitus, Type 2
- Autoimmune Diseases
- Adipose Tissue
- 3204 Immunology
- 3105 Genetics
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Receptors, Leptin
- Obesity
- Leptin
- Infections
- Humans
- Diabetes Mellitus, Type 2
- Autoimmune Diseases
- Adipose Tissue
- 3204 Immunology
- 3105 Genetics