The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.

Journal Article (Journal Article;Review)

Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic metabolism and appetite, leptin displays pleiotropic actions, and it is now clear that leptin has a key role in influencing immune cell function. Indeed, many immune cells have been shown to respond to leptin directly via the leptin receptor, resulting in a largely pro-inflammatory phenotype. Understanding the role of adipose-tissue derived mediators in inflammation is critical to determining the pathophysiology of multiple obesity-associated diseases, such as type 2 diabetes, autoimmune disease, and infection. This review, therefore, focuses on the latest data regarding the role of leptin in modulating inflammation.

Full Text

Duke Authors

Cited Authors

  • Kiernan, K; MacIver, NJ

Published Date

  • 2020

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 622468 -

PubMed ID

  • 33584724

Pubmed Central ID

  • PMC7878386

Electronic International Standard Serial Number (EISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2020.622468


  • eng

Conference Location

  • Switzerland