Xenobiotic metabolism and transport in Caenorhabditis elegans .

Journal Article (Review;Journal Article)

Caenorhabditis elegans has emerged as a major model in biomedical and environmental toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been published, and this species has now been adopted by investigators in academic toxicology, pharmacology, and drug discovery labs. C. elegans has also attracted the interest of governmental regulatory agencies charged with evaluating the safety of chemicals. However, a major, fundamental aspect of toxicological science remains underdeveloped in C. elegans : xenobiotic metabolism and transport processes that are critical to understanding toxicokinetics and toxicodynamics, and extrapolation to other species. The aim of this review was to initially briefly describe the history and trajectory of the use of C. elegans in toxicological and pharmacological studies. Subsequently, physical barriers to chemical uptake and the role of the worm microbiome in xenobiotic transformation were described. Then a review of what is and is not known regarding the classic Phase I, Phase II, and Phase III processes was performed. In addition, the following were discussed (1) regulation of xenobiotic metabolism; (2) review of published toxicokinetics for specific chemicals; and (3) genetic diversity of these processes in C. elegans . Finally, worm xenobiotic transport and metabolism was placed in an evolutionary context; key areas for future research highlighted; and implications for extrapolating C. elegans toxicity results to other species discussed.

Full Text

Duke Authors

Cited Authors

  • Hartman, JH; Widmayer, SJ; Bergemann, CM; King, DE; Morton, KS; Romersi, RF; Jameson, LE; Leung, MCK; Andersen, EC; Taubert, S; Meyer, JN

Published Date

  • February 22, 2021

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 51 - 94

PubMed ID

  • 33616007

Pubmed Central ID

  • PMC7958427

Electronic International Standard Serial Number (EISSN)

  • 1521-6950

International Standard Serial Number (ISSN)

  • 1093-7404

Digital Object Identifier (DOI)

  • 10.1080/10937404.2021.1884921

Language

  • eng