TRPA1: An asthma target with a zing.

Journal Article (Journal Article)

Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and reactive endogenous mediators, suppresses inflammation and airway smooth muscle contraction in several preclinical species.

Full Text

Duke Authors

Cited Authors

  • Jordt, S-E

Published Date

  • April 5, 2021

Published In

Volume / Issue

  • 218 / 4

PubMed ID

  • 33625497

Pubmed Central ID

  • PMC7918757

Electronic International Standard Serial Number (EISSN)

  • 1540-9538

Digital Object Identifier (DOI)

  • 10.1084/jem.20202507

Language

  • eng

Conference Location

  • United States