Sweet dreams: Therapeutic insights, targeting imaging and physiologic evidence linking sleep, melatonin and diabetic nephropathy

Journal Article (Review;Journal)

Melatonin is the main biochronologic molecular mediator of circadian rhythm and sleep. It is also a powerful antioxidant and has roles in other physiologic pathways. Melatonin deficiency is associated with metabolic derangements including glucose and cholesterol dysregulation, hypertension, disordered sleep and even cancer, likely due to altered immunity. Diabetic nephropathy (DN) is a key microvascular complication of both type 1 and 2 diabetes. DN is the end result of a complex combination of metabolic, haemodynamic, oxidative and inflammatory factors. Interestingly, these same factors have been linked to melatonin deficiency. This report will collate in a clinician-oriented fashion the mechanistic link between melatonin deficiency and factors contributing to DN.

Full Text

Duke Authors

Cited Authors

  • Afsar, B; Afsar, RE; Sag, AA; Kanbay, A; Korkmaz, H; Cipolla-Neto, J; Covic, A; Ortiz, A; Kanbay, M

Published Date

  • January 1, 2020

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 522 - 530

Electronic International Standard Serial Number (EISSN)

  • 2048-8513

International Standard Serial Number (ISSN)

  • 2048-8505

Digital Object Identifier (DOI)

  • 10.1093/CKJ/SFZ198

Citation Source

  • Scopus