A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: The replenishment of lost or damaged myocardium has the potential to reverse heart failure, making heart regeneration a goal for cardiovascular medicine. Unlike adult mammals, injury to the zebrafish or neonatal mouse heart induces a robust regenerative program with minimal scarring. Recent insights into the cellular and molecular mechanisms of heart regeneration suggest that the machinery for regeneration is conserved from zebrafish to mammals. Here, we will review conserved mechanisms of heart regeneration and their translational implications. RECENT FINDINGS: Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics.

Full Text

Duke Authors

Cited Authors

  • Brezitski, KD; Goff, AW; DeBenedittis, P; Karra, R

Published Date

  • March 2, 2021

Published In

Volume / Issue

  • 23 / 4

Start / End Page

  • 29 -

PubMed ID

  • 33655359

Pubmed Central ID

  • PMC8063206

Electronic International Standard Serial Number (EISSN)

  • 1534-3170

Digital Object Identifier (DOI)

  • 10.1007/s11886-021-01459-6


  • eng

Conference Location

  • United States