Bioethical, Reproducibility, and Translational Challenges of Animal Models.

Journal Article (Journal Article;Review)

There is no prescribed stage or standardized point at which an animal model protocol is reviewed for reproducibility and translatability. The method of review for a reproducible and translatable study is not consistently documented in peer literature, and this is a major challenge for those working with animal models of human diseases. If the study is ill designed, it is impossible to perform an accurate harm/benefit analysis. In addition, there may be an ethical challenge if the work is not reproducible and translatable. Animal welfare regulations and other documents of control clearly state the role of the Institutional Animal Care and Use Committees are to look at science justification within the context of animal welfare. This article, concentrating on models not governed by regulations, outlines issues and offers recommendations for refining animal model review with a goal to improve study reproducibility and translatability.

Full Text

Duke Authors

Cited Authors

  • Landi, M; Everitt, J; Berridge, B

Published Date

  • December 31, 2021

Published In

Volume / Issue

  • 62 / 1-2

Start / End Page

  • 60 - 65

PubMed ID

  • 33693624

Pubmed Central ID

  • PMC9291343

Electronic International Standard Serial Number (EISSN)

  • 1930-6180

Digital Object Identifier (DOI)

  • 10.1093/ilar/ilaa027


  • eng

Conference Location

  • England