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Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies.

Publication ,  Journal Article
Povsic, TJ; Sanz-Ruiz, R; Climent, AM; Bolli, R; Taylor, DA; Gersh, BJ; Menasché, P; Perin, EC; Pompilio, G; Atsma, DE; Badimon, L; Hare, JM ...
Published in: ESC Heart Fail
June 2021

The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.

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Published In

ESC Heart Fail

DOI

EISSN

2055-5822

Publication Date

June 2021

Volume

8

Issue

3

Start / End Page

2306 / 2309

Location

England

Related Subject Headings

  • Stem Cell Transplantation
  • Regeneration
  • Humans
  • Heart
  • Cell- and Tissue-Based Therapy
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Povsic, T. J., Sanz-Ruiz, R., Climent, A. M., Bolli, R., Taylor, D. A., Gersh, B. J., … Fernández-Avilés, F. (2021). Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Fail, 8(3), 2306–2309. https://doi.org/10.1002/ehf2.13256
Povsic, Thomas J., Ricardo Sanz-Ruiz, Andreu M. Climent, Roberto Bolli, Doris A. Taylor, Bernard J. Gersh, Philippe Menasché, et al. “Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies.ESC Heart Fail 8, no. 3 (June 2021): 2306–9. https://doi.org/10.1002/ehf2.13256.
Povsic TJ, Sanz-Ruiz R, Climent AM, Bolli R, Taylor DA, Gersh BJ, et al. Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Fail. 2021 Jun;8(3):2306–9.
Povsic, Thomas J., et al. “Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies.ESC Heart Fail, vol. 8, no. 3, June 2021, pp. 2306–09. Pubmed, doi:10.1002/ehf2.13256.
Povsic TJ, Sanz-Ruiz R, Climent AM, Bolli R, Taylor DA, Gersh BJ, Menasché P, Perin EC, Pompilio G, Atsma DE, Badimon L, DeMaria AN, Hare JM, Henry TD, Janssens S, Kastrup J, Torella D, Traverse JH, Willerson JT, Fernández-Avilés F. Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Fail. 2021 Jun;8(3):2306–2309.
Journal cover image

Published In

ESC Heart Fail

DOI

EISSN

2055-5822

Publication Date

June 2021

Volume

8

Issue

3

Start / End Page

2306 / 2309

Location

England

Related Subject Headings

  • Stem Cell Transplantation
  • Regeneration
  • Humans
  • Heart
  • Cell- and Tissue-Based Therapy
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology