Visualizing the dynamics of tuberculosis pathology using molecular imaging.

Journal Article (Journal Article;Review)

Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.

Full Text

Duke Authors

Cited Authors

  • Ordonez, AA; Tucker, EW; Anderson, CJ; Carter, CL; Ganatra, S; Kaushal, D; Kramnik, I; Lin, PL; Madigan, CA; Mendez, S; Rao, J; Savic, RM; Tobin, DM; Walzl, G; Wilkinson, RJ; Lacourciere, KA; Via, LE; Jain, SK

Published Date

  • March 1, 2021

Published In

Volume / Issue

  • 131 / 5

PubMed ID

  • 33645551

Pubmed Central ID

  • PMC7919721

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI145107

Language

  • eng

Conference Location

  • United States