Temporal changes in allostatic load patterns by age, race/ethnicity, and gender among the US adult population; 1988-2018.

Journal Article (Journal Article)

The objective of this study is to provide an assessment of allostatic load (AL) burden among US adults across race/ethnicity, gender, and age groups over a 30-year time period. We analyzed data from 50,671 participants of the National Health and Nutrition Examination Survey (NHANES) years 1988 through 2018. AL score was defined as the sum total for abnormal measures of the following components: serum albumin, body mass index, serum C - reactive protein, serum creatinine, diastolic blood pressure, glycated hemoglobin, systolic blood pressure, total cholesterol, and serum triglycerides. We performed modified Poisson regression to estimate the adjusted Relative Risks (aRRs) of allostatic load, and generalized linear models to determine adjusted mean differences accounting for NHANES sampling weights. Among US adults aged 18 or older, the prevalence of high AL increased by more than 45% from 1988 to 1991 to 2015-2018, from 33.5% to 48.6%. By the latest period, 2015-2018, Non-Hispanic Black women (aRR: 1.292; 95% CI: 1.290-1.293) and Latina women (aRR: 1.266; 95% CI: 1.265-1.267) had higher risks of AL than non-Hispanic White women. Similar trends were observed among men. Age-adjusted mean AL score among NH-Black and Latinx adults was higher than for NH-Whites of up to a decade older regardless of gender. From 1988 through 2018, Adults aged 40 years old and older had over 2-fold increased risks of high AL when compared to adults 18-29 years old. After 30-years of collective data, racial disparities in allostatic load persist for NH-Black and Latinx adults.

Full Text

Duke Authors

Cited Authors

  • Moore, JX; Bevel, MS; Aslibekyan, S; Akinyemiju, T

Published Date

  • June 2021

Published In

Volume / Issue

  • 147 /

Start / End Page

  • 106483 -

PubMed ID

  • 33640399

Pubmed Central ID

  • PMC8826516

Electronic International Standard Serial Number (EISSN)

  • 1096-0260

Digital Object Identifier (DOI)

  • 10.1016/j.ypmed.2021.106483


  • eng

Conference Location

  • United States