Skip to main content
Journal cover image

Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern.

Publication ,  Journal Article
Coleman, KK; Robie, ER; Abdelgadir, A; Kozhumam, AS; Binder, RA; Gray, GC
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
August 2021

Human adenovirus type 4 (HAdV-E4) frequently causes epidemics among military and civilian populations. We conducted a systematic review of 144 peer-reviewed articles reporting HAdV-E4 infections, published during the years 1960-2020. More than 24 500 HAdV-E4 infections, including 27 associated deaths, were documented. HAdV-E4 infections were reported from all geographic regions of the world except Central America and the Caribbean. The number of publications reporting civilian infections tripled in the last decade, with a steady increase in reported civilian infections over time. Infections commonly caused respiratory and ocular disease. North America reported the most infections, followed by Asia and Europe. The majority of deaths were reported in the United States, followed by China and Singapore. Civilians seem to increasingly suffer HAdV-E4 disease, with recent epidemics among US college students. Public health officials should consider seeking emergency use authorization for the adenovirus vaccine such that it might be available to mitigate civilian epidemics.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

August 2021

Volume

73

Issue

4

Start / End Page

740 / 746

Related Subject Headings

  • United States
  • Respiratory Tract Infections
  • Military Personnel
  • Microbiology
  • Humans
  • China
  • Adenoviruses, Human
  • Adenovirus Infections, Human
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Coleman, K. K., Robie, E. R., Abdelgadir, A., Kozhumam, A. S., Binder, R. A., & Gray, G. C. (2021). Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 73(4), 740–746. https://doi.org/10.1093/cid/ciab146
Coleman, Kristen K., Emily R. Robie, Anfal Abdelgadir, Arthi S. Kozhumam, Raquel A. Binder, and Gregory C. Gray. “Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 73, no. 4 (August 2021): 740–46. https://doi.org/10.1093/cid/ciab146.
Coleman KK, Robie ER, Abdelgadir A, Kozhumam AS, Binder RA, Gray GC. Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Aug;73(4):740–6.
Coleman, Kristen K., et al. “Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, vol. 73, no. 4, Aug. 2021, pp. 740–46. Epmc, doi:10.1093/cid/ciab146.
Coleman KK, Robie ER, Abdelgadir A, Kozhumam AS, Binder RA, Gray GC. Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Aug;73(4):740–746.
Journal cover image

Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

August 2021

Volume

73

Issue

4

Start / End Page

740 / 746

Related Subject Headings

  • United States
  • Respiratory Tract Infections
  • Military Personnel
  • Microbiology
  • Humans
  • China
  • Adenoviruses, Human
  • Adenovirus Infections, Human
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences