Epigenomic links from metabolism-methionine and chromatin architecture.

Journal Article (Journal Article;Review)

Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures, including physiological stress, nutritional deprivation, and starvation. Numerous studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure (e.g. chromatin compaction, nucleosome arrangement, and chromatin loops) and how they appropriately deposit specific chemical modification on chromatin are largely unknown. Here, focusing on methionine metabolism, we discuss recent developments of metabolic effects on chromatin modifications and structure, as well as consequences on gene regulation.

Full Text

Duke Authors

Cited Authors

  • Xiao, Z; Locasale, JW

Published Date

  • August 2021

Published In

Volume / Issue

  • 63 /

Start / End Page

  • 11 - 18

PubMed ID

  • 33667809

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

Digital Object Identifier (DOI)

  • 10.1016/j.cbpa.2021.01.011

Language

  • eng

Conference Location

  • England