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Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes.

Publication ,  Journal Article
Tay, J; Beattie, S; Bredeson, C; Brazauskas, R; He, N; Ahmed, IA; Aljurf, M; Askar, M; Atsuta, Y; Badawy, S; Barata, A; Beitinjaneh, AM ...
Published in: Curr Oncol
December 1, 2020

Background: Evidence about the impact of marital status before hematopoietic cell transplantation (hct) on outcomes after hct is conflicting. Methods: We identified patients 40 years of age and older within the Center for International Blood and Marrow Transplant Research registry who underwent hct between January 2008 and December 2015. Marital status before hct was declared as one of: married or living with a partner, single (never married), separated or divorced, and widowed. We performed a multivariable analysis to determine the association of marital status with outcomes after hct. Results: We identified 10,226 allogeneic and 5714 autologous hct cases with, respectively, a median follow-up of 37 months (range: 1-102 months) and 40 months (range: 1-106 months). No association between marital status and overall survival was observed in either the allogeneic (p = 0.58) or autologous (p = 0.17) setting. However, marital status was associated with grades 2-4 acute graft-versus-host disease (gvhd), p < 0.001, and chronic gvhd, p = 0.04. The risk of grades 2-4 acute gvhd was increased in separated compared with married patients [hazard ratio (hr): 1.13; 95% confidence interval (ci): 1.03 to 1.24], and single patients had a reduced risk of grades 2-4 acute gvhd (hr: 0.87; 95% ci: 0.77 to 0.98). The risk of chronic gvhd was lower in widowed compared with married patients (hr: 0.82; 95% ci: 0.67 to 0.99). Conclusions: Overall survival after hct is not influenced by marital status, but associations were evident between marital status and grades 2-4 acute and chronic gvhd. To better appreciate the effects of marital status and social support, future research should consider using validated scales to measure social support and patient and caregiver reports of caregiver commitment, and to assess health-related quality of life together with health care utilization.

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Published In

Curr Oncol

DOI

EISSN

1718-7729

Publication Date

December 1, 2020

Volume

27

Issue

6

Start / End Page

596 / 606

Location

Switzerland

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Tay, J., Beattie, S., Bredeson, C., Brazauskas, R., He, N., Ahmed, I. A., … Saber, W. (2020). Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes. Curr Oncol, 27(6), 596–606. https://doi.org/10.3747/co.27.6327
Tay, J., S. Beattie, C. Bredeson, R. Brazauskas, N. He, I. A. Ahmed, M. Aljurf, et al. “Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes.Curr Oncol 27, no. 6 (December 1, 2020): 596–606. https://doi.org/10.3747/co.27.6327.
Tay J, Beattie S, Bredeson C, Brazauskas R, He N, Ahmed IA, et al. Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes. Curr Oncol. 2020 Dec 1;27(6):596–606.
Tay, J., et al. “Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes.Curr Oncol, vol. 27, no. 6, Dec. 2020, pp. 596–606. Pubmed, doi:10.3747/co.27.6327.
Tay J, Beattie S, Bredeson C, Brazauskas R, He N, Ahmed IA, Aljurf M, Askar M, Atsuta Y, Badawy S, Barata A, Beitinjaneh AM, Bhatt NS, Buchbinder D, Cerny J, Ciurea S, D’Souza A, Dalal J, Farhadfar N, Freytes CO, Ganguly S, Gergis U, Gerull S, Lazarus HM, Hahn T, Hong S, Inamoto Y, Khera N, Kindwall-Keller T, Kamble RT, Knight JM, Koleva YN, Kumar A, Kwok J, Murthy HS, Olsson RF, Angel Diaz-Perez M, Rizzieri D, Seo S, Chhabra S, Schoemans H, Schouten HC, Steinberg A, Sullivan KM, Szer J, Szwajcer D, Ulrickson ML, Verdonck LF, Wirk B, Wood WA, Yared JA, Saber W. Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes. Curr Oncol. 2020 Dec 1;27(6):596–606.

Published In

Curr Oncol

DOI

EISSN

1718-7729

Publication Date

December 1, 2020

Volume

27

Issue

6

Start / End Page

596 / 606

Location

Switzerland

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis