Masses of the Lacrimal Gland: Evaluation and Treatment

Journal Article (Review;Journal)

Lacrimal gland lesions account for approximately 9 to 10% of all biopsied orbital masses. Potential causes include nongranulomatous and granulomatous inflammation, autoimmune disease, lymphoproliferative disorders, benign epithelial proliferation, malignant neoplasia, and metastatic disease. Inflammatory lesions and lymphoproliferative disorders are the most common and may be unilateral or bilateral; they may also be localized to the orbit or associated with systemic disease. Both benign and malignant epithelial lacrimal gland masses tend to be unilateral and involve the orbital lobe, but a more rapid onset of symptoms and periorbital pain strongly suggest malignant disease. On orbital imaging, both inflammatory and lymphoproliferative lesions conform to the globe and surrounding structures, without changes in adjacent bone, whereas epithelial lacrimal gland masses often show scalloping of the lacrimal gland fossa. Malignant epithelial lacrimal gland tumors can also have radiographic evidence of bony invasion and destruction. Masses of the lacrimal gland may be due to a broad range of pathologies, and a good working knowledge of common clinical characteristics and radiographic imaging findings is essential for diagnosis and treatment. All patients with inflammatory, lymphoproliferative, and epithelial neoplastic lesions involving the lacrimal gland require long-term surveillance for disease recurrence and progression.

Full Text

Duke Authors

Cited Authors

  • Kim, JS; Liss, J

Published Date

  • February 1, 2021

Published In

Volume / Issue

  • 82 / 1

Start / End Page

  • 100 - 106

Electronic International Standard Serial Number (EISSN)

  • 2193-6331

International Standard Serial Number (ISSN)

  • 2193-634X

Digital Object Identifier (DOI)

  • 10.1055/s-0040-1722700

Citation Source

  • Scopus