SOCE in the cardiomyocyte: the secret is in the chambers.

Journal Article (Review;Journal Article)

Store-operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway that is present in virtually every cell type. Over the last two decades, many studies have implicated this non-voltage dependent Ca2+ entry pathway in cardiac physiology. The relevance of the SOCE pathway in cardiomyocytes is often questioned given the well-established role for excitation contraction coupling. In this review, we consider the evidence that STIM1 and SOCE contribute to Ca2+ dynamics in cardiomyocytes. We discuss the relevance of this pathway to cardiac growth in response to developmental and pathologic cues. We also address whether STIM1 contributes to Ca2+ store refilling that likely impacts cardiac pacemaking and arrhythmogenesis in cardiomyocytes.

Full Text

Duke Authors

Cited Authors

  • Rosenberg, P; Zhang, H; Bryson, VG; Wang, C

Published Date

  • March 2021

Published In

Volume / Issue

  • 473 / 3

Start / End Page

  • 417 - 434

PubMed ID

  • 33638008

Pubmed Central ID

  • PMC7910201

Electronic International Standard Serial Number (EISSN)

  • 1432-2013

International Standard Serial Number (ISSN)

  • 0031-6768

Digital Object Identifier (DOI)

  • 10.1007/s00424-021-02540-3

Language

  • eng