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Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence

Publication ,  Conference
Peres, LC; Camacho, TF; Bandera, EV; Bethea, TN; Joslin, CE; Wu, AH; Beeghly-Fadiel, A; Cloyd, EK; Harris, HR; Moorman, PG; Myers, E ...
Published in: Cancer Research
August 15, 2020

Purpose. Although the incidence of epithelial ovarian cancer is highest among non-Hispanic white women, African-American women have the worst survival of all racial/ethnic groups. We hypothesize that differences in the prevalence of known and suspected ovarian cancer risk factors may explain a portion of the differences in incidence of epithelial ovarian cancer between white and African-American women.Methods. We used data from seven U.S. studies in the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium, the North Carolina Ovarian Cancer Study (NCOCS), the Los Angeles Ovarian Cancer Study (LACOCS), the African-American Cancer Epidemiology Study (AACES), the Cook County Case-Control Study (CCCCS), the Black Women's Health Study (BWHS), the Women's Health Initiative (WHI), and the Multiethnic Cohort Study (MEC). The association between each known or suspected ovarian cancer risk factor (age, parity, oral contraceptive use, tubal ligation, body mass index (BMI), family history of ovarian and breast cancer, menopausal status, education, hysterectomy, aspirin use, talcum powder applied to genital areas, endometriosis, and age at menarche) was estimated using logistic regression with study site interactions to capture heterogeneity across studies. Using the Bruzzi method, population attributable risks (PAR) were calculated by race for each risk factor individually and collectively for all risk factors.Results. The comparison of 3,249 white ovarian cancer cases and 9,650 controls to 1,054 African-American cases and 2,410 controls revealed notable differences in the PAR of several risk factors by race. African-American women had a statistically significantly higher PAR for family history of breast cancer and BMI ≥30kg/m2compared to white women (10.0% vs. 2.5% and 8.9% vs. 0.4%, respectively). Although not statistically significant, white women had a higher PAR for oral contraceptive use (duration <5 years) and not having had a tubal ligation than African-American women. When evaluating all risk factors collectively, the overall PAR was 63.9% for African-American women and 48.0% for white women. We also calculated overall PARs excluding WHI due to differences in the inclusion criteria for WHI compared to the other population-based studies in OCWAA: 65.7% for African-American women and 57.8% for white women.Conclusions. Our findings suggest that the known and suspected ovarian cancer risk factors investigated in this study may be partially responsible for differences in ovarian cancer incidence between white and African-American women. Although important across both racial groups, collectively, the factors studied accounted for slightly more of the ovarian cancer risk among African-American women than white women.Citation Format: Lauren C. Peres, Tareq F. Camacho, Elisa V. Bandera, Traci N. Bethea, Charlotte E. Joslin, Anna H. Wu, Alicia Beeghly-Fadiel, Emily K. Cloyd, Holly R. Harris, Patricia G. Moorman, Evan Myers, Heather M. Ochs-Balcom, Will L. Rosenow, Veronica W. Setiawan, Lynn Rosenberg, Joellen M. Schildkraut. Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1180.

Duke Scholars

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

August 15, 2020

Volume

80

Issue

16_Supplement

Start / End Page

1180 / 1180

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

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Peres, L. C., Camacho, T. F., Bandera, E. V., Bethea, T. N., Joslin, C. E., Wu, A. H., … Schildkraut, J. M. (2020). Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence. In Cancer Research (Vol. 80, pp. 1180–1180). American Association for Cancer Research (AACR). https://doi.org/10.1158/1538-7445.am2020-1180
Peres, Lauren C., Tareq F. Camacho, Elisa V. Bandera, Traci N. Bethea, Charlotte E. Joslin, Anna H. Wu, Alicia Beeghly-Fadiel, et al. “Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence.” In Cancer Research, 80:1180–1180. American Association for Cancer Research (AACR), 2020. https://doi.org/10.1158/1538-7445.am2020-1180.
Peres LC, Camacho TF, Bandera EV, Bethea TN, Joslin CE, Wu AH, et al. Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence. In: Cancer Research. American Association for Cancer Research (AACR); 2020. p. 1180–1180.
Peres, Lauren C., et al. “Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence.” Cancer Research, vol. 80, no. 16_Supplement, American Association for Cancer Research (AACR), 2020, pp. 1180–1180. Crossref, doi:10.1158/1538-7445.am2020-1180.
Peres LC, Camacho TF, Bandera EV, Bethea TN, Joslin CE, Wu AH, Beeghly-Fadiel A, Cloyd EK, Harris HR, Moorman PG, Myers E, Ochs-Balcom HM, Rosenow WL, Setiawan VW, Rosenberg L, Schildkraut JM. Abstract 1180: Estimating the contribution of epidemiologic risk factors to racial differences in epithelial ovarian cancer incidence. Cancer Research. American Association for Cancer Research (AACR); 2020. p. 1180–1180.

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

August 15, 2020

Volume

80

Issue

16_Supplement

Start / End Page

1180 / 1180

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis