Health-related quality of life in children with untreated intermittent exotropia and their parents.

Journal Article (Journal Article)

PURPOSE: To determine whether health-related quality of life (HRQOL) scores improved or worsened over 3 years of observation in childhood intermittent exotropia without treatment. METHODS: A total of 111 children aged 3-11 years with intermittent exotropia were assigned to observation in a previously reported randomized trial comparing patching with observation. The intermittent exotropia questionnaire (IXTQ) was administered at baseline, 6 months, and 36 months. Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery) were compared between time points. The Child IXTQ was administered only to children ≥5 years of age (n = 78). RESULTS: Overall, Child IXTQ and Proxy IXTQ scores showed no significant change over 36 months (mean improvement from baseline to 36 months of 3.2 points [95% CI, -1.9 to 8.2] and -2.4 points [95% CI: -7.9 to 3.1], resp.). By contrast, Parent-psychosocial, Parent-function, and Parent-surgery domain scores all improved over 36 months (mean improvements of 12.8 points [95% CI, 5.9-19.6] and 14.2 points [95% CI, 8.0-20.3] and 18.5 points [95% CI, 9.7-27.3], resp.). CONCLUSIONS: HRQOL of children with intermittent exotropia remains stable with observation over 3 years (by both child and proxy report), whereas parental HRQOL improves.

Full Text

Duke Authors

Cited Authors

  • Holmes, JM; Hercinovic, A; Melia, BM; Leske, DA; Hatt, SR; Chandler, DL; Dean, TW; Kraker, RT; Enyedi, LB; Wallace, DK; Mohney, BG; Cotter, SA; Pediatric Eye Disease Investigator Group,

Published Date

  • April 2021

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 80.e1 - 80.e4

PubMed ID

  • 33705917

Pubmed Central ID

  • PMC8628477

Electronic International Standard Serial Number (EISSN)

  • 1528-3933

Digital Object Identifier (DOI)

  • 10.1016/j.jaapos.2020.10.011


  • eng

Conference Location

  • United States