PD-1 and PD-L1 expression in cardiac transplantation.
Journal Article (Journal Article;Review)
Programmed death-ligand 1 (PD-L1), a transmembrane protein and member of the CD28 T cell family is associated with lymphocyte activation.1 PD-L1 expression is upregulated on activated antigen presenting cells such as monocytes, myeloid and dendritic cells.2 When bound to its cognate receptor programmed cell death (PD-1), inhibition of immune responses including downregulation of T cell proliferation occurs.3 Mechanistically, such inhibition would be hypothetically favorable in the setting of a transplanted organ undergoing allograft rejection. However, there is a paucity of data addressing the role of PD-L1 and PD-1 expression in the human transplanted heart.
Full Text
Duke Authors
- Bishawi, Muath
- Bowles, Dawn Elizabeth
- Glass, Carolyn
- Mendiola Pla, Michelle
- Milano, Carmelo Alessio
- Schroder, Jacob Niall
Cited Authors
- Bishawi, M; Bowles, D; Pla, MM; Oakes, F; Chiang, Y; Schroder, J; Milano, C; Glass, C
Published Date
- 2021
Published In
Volume / Issue
- 54 /
Start / End Page
- 107331 -
PubMed ID
- 33737091
Electronic International Standard Serial Number (EISSN)
- 1879-1336
Digital Object Identifier (DOI)
- 10.1016/j.carpath.2021.107331
Language
- eng
Conference Location
- United States