Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.

Journal Article (Journal Article)

In contrast to recommendations for young and middle-aged adults, intentional weight loss among older adults remains controversial and is inconsistently advised. Recent research suggests that a higher protein diet can mitigate loss of lean mass during periods of intentional weight loss among older adults with obesity; however, the effects of intentional weight loss on skeletal muscle and bone are not fully understood. The Dairy in the Diet Yields New Approaches for Muscle Optimization (DDYNAMO) trial is a 6-month, randomized, controlled pilot study assessing the effects of combining regular, generous intakes of high quality protein (30 g/meal; primarily from dairy) with caloric restriction (-500kcal/d) and low-intensity resistance exercise (30 min/3 times per week) on muscle quality, muscle composition, bone mineral density in men and women aged ≥60 years with obesity and mild to moderate functional impairment (Short Physical Performance Battery [SPPB] score ≥4 to ≤10). Participants will be re-assessed at 18 months to evaluate weight maintenance, bone mineral density, physical function, and other secondary measures. ClinicalTrials.gov Identifier: NCT02437643.

Full Text

Duke Authors

Cited Authors

  • Miller, MG; Porter Starr, KN; Rincker, J; Orenduff, MC; McDonald, SR; Pieper, CF; Fruik, AR; Lyles, KW; Bales, CW

Published Date

  • 2021

Published In

Volume / Issue

  • 40 / 2-3

Start / End Page

  • 150 - 170

PubMed ID

  • 33719918

Pubmed Central ID

  • PMC9351499

Electronic International Standard Serial Number (EISSN)

  • 2155-1200

Digital Object Identifier (DOI)

  • 10.1080/21551197.2021.1896615


  • eng

Conference Location

  • United States