Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium.

Journal Article (Journal Article)

BACKGROUND: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. METHODS: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States. RESULTS: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk. CONCLUSIONS: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. IMPACT: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.

Full Text

Duke Authors

Cited Authors

  • Lo, C-H; Blot, WJ; Teras, LR; Visvanathan, K; Le Marchand, L; Haiman, CA; Chen, Y; Sesso, HD; Wassertheil-Smoller, S; Tinker, LF; Peek, RM; Potter, JD; Cover, TL; Zeleniuch-Jacquotte, A; Berndt, SI; Waterboer, T; Epplein, M; Butt, J; Song, M

Published Date

  • June 2021

Published In

Volume / Issue

  • 30 / 6

Start / End Page

  • 1279 - 1282

PubMed ID

  • 33737297

Pubmed Central ID

  • PMC8172443

Electronic International Standard Serial Number (EISSN)

  • 1538-7755

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-20-1471

Language

  • eng

Conference Location

  • United States