Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: The purpose of this review is to recognize clinical features of Paget's disease of bone and to describe how the osteoclast, a myeloid-derived cell responsible for bone resorption, contributes to the disease. RECENT FINDINGS: Recent studies have identified several variants in SQSTM1, OPTN, and other genes that may predispose individuals to Paget's disease of bone; studies of these genes and their protein products have elucidated new roles for these proteins in bone physiology. Understanding the pathologic mechanisms in the Pagetic osteoclast may lead to the identification of future treatment targets for other inflammatory and autoimmune diseases characterized by abnormal bone erosion and/or osteoclast activation.

Full Text

Duke Authors

Cited Authors

  • Rabjohns, EM; Hurst, K; Ghosh, A; Cuellar, MC; Rampersad, RR; Tarrant, TK

Published Date

  • March 25, 2021

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 23 -

PubMed ID

  • 33768371

Electronic International Standard Serial Number (EISSN)

  • 1534-6315

Digital Object Identifier (DOI)

  • 10.1007/s11882-021-01001-2


  • eng

Conference Location

  • United States