Spontaneous intracranial hypotension syndrome treated with fludrocortisone.

Journal Article (Journal Article)

Spontaneous intracranial hypotension is a rare syndrome characterized by orthostatic headache not associated with trauma or dural puncture. In most cases, it is caused by a spontaneous spinal cerebrospinal fluid leakage as demonstrated by neuroradiological studies. The standard of care consists of conservative treatment including bed rest, hydration, and administration of caffeine or glucocorticoids. When such conservative therapy fails, an epidural blood patch is recommended. In this report, we describe the treatment of 2 patients with spontaneous intracranial hypotension who failed conservative treatment and went on to have complete and sustained resolution of their symptoms after the administration of oral fludrocortisone.

Full Text

Duke Authors

Cited Authors

  • Rizk, M; El Khatib, M; Yamout, B; Hujeily, E; Ayoub, S; Ayoub, C; Skaf, G

Published Date

  • January 1, 2015

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 8 - 11

PubMed ID

  • 25612272

Electronic International Standard Serial Number (EISSN)

  • 2325-7237

Digital Object Identifier (DOI)

  • 10.1213/XAA.0000000000000105


  • eng

Conference Location

  • United States