NailQoL: a quality-of-life instrument for onychomycosis.

Journal Article (Journal Article)

BACKGROUND: The disease burden onychomycosis is not trivial. The aim is to develop a quality of life instrument to measure the onychomycosis burden. METHODS: 402 patients with mycologically-confirmed onychomycosis completed a baseline questionnaire of 39 quality of life items (modified Skindex-29 questions and 10 additional nail-specific questions). Internal consistency, reproducibility and responsiveness of the final instrument, NailQoL were measured. RESULTS: 15 items consisting of symptom (3), emotion (10), and functional (2) domains were retained in NailQoL. Symptom and emotion subscales = 0.80-0.92. Administration alpha demonstrated good internal consistency (Cronbach's of the instrument to 46 patients at one month after baseline revealed good reproducibility (ICC 0.88-0.91). Responsiveness was measured in 292 patients at 18 months; statistically significant better NailQoL scores were found in individuals with complete cure (mycological and clinical) (P < 0.01). CONCLUSION: NailQoL represents a new concise, valid, reliable, and responsive instrument for measuring burden of skin disease for patients with onychomycosis.

Full Text

Duke Authors

Cited Authors

  • Warshaw, EM; Foster, JK; Cham, PMH; Grill, JP; Chen, SC

Published Date

  • December 2007

Published In

Volume / Issue

  • 46 / 12

Start / End Page

  • 1279 - 1286

PubMed ID

  • 18173524

International Standard Serial Number (ISSN)

  • 0011-9059

Digital Object Identifier (DOI)

  • 10.1111/j.1365-4632.2007.03362.x


  • eng

Conference Location

  • England