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Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.

Publication ,  Journal Article
Verhoef, PA; Kannan, S; Sturgill, JL; Tucker, EW; Morris, PE; Miller, AC; Sexton, TR; Koyner, JL; Hejal, R; Brakenridge, SC; Moldawer, LL ...
Published in: Crit Care Explor
March 2021

OBJECTIVES: Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome-associated coronavirus 2 virus enters cells via the angiotensin-converting enzyme 2 receptor and activates several distinct inflammatory pathways, resulting in hematologic abnormalities and dysfunction in respiratory, cardiac, gastrointestinal renal, endocrine, dermatologic, and neurologic systems. This review summarizes the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research. DATA SOURCES: Investigators from the Research Section of the Society of Critical Care Medicine were selected based on expertise in specific organ systems and research focus. Data were obtained from searches conducted in Medline via the PubMed portal, Directory of Open Access Journals, Excerpta Medica database, Latin American and Caribbean Health Sciences Literature, and Web of Science from an initial search from December 2019 to October 15, 2020, with a revised search to February 3, 2021. The medRxiv, Research Square, and clinical trial registries preprint servers also were searched to limit publication bias. STUDY SELECTION: Content experts selected studies that included mechanism-based relevance to the severe acute respiratory syndrome-associated coronavirus 2 virus or coronavirus disease 2019 disease. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Not applicable. CONCLUSIONS: Efforts to improve the care of critically ill coronavirus disease 2019 patients should be centered on understanding how severe acute respiratory syndrome-associated coronavirus 2 infection affects organ function. This review articulates specific targets for further research.

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Published In

Crit Care Explor

DOI

EISSN

2639-8028

Publication Date

March 2021

Volume

3

Issue

3

Start / End Page

e0374

Location

United States

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Verhoef, P. A., Kannan, S., Sturgill, J. L., Tucker, E. W., Morris, P. E., Miller, A. C., … Remy, K. E. (2021). Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor, 3(3), e0374. https://doi.org/10.1097/CCE.0000000000000374
Verhoef, Philip A., Sujatha Kannan, Jamie L. Sturgill, Elizabeth W. Tucker, Peter E. Morris, Andrew C. Miller, Travis R. Sexton, et al. “Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.Crit Care Explor 3, no. 3 (March 2021): e0374. https://doi.org/10.1097/CCE.0000000000000374.
Verhoef PA, Kannan S, Sturgill JL, Tucker EW, Morris PE, Miller AC, et al. Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor. 2021 Mar;3(3):e0374.
Verhoef, Philip A., et al. “Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.Crit Care Explor, vol. 3, no. 3, Mar. 2021, p. e0374. Pubmed, doi:10.1097/CCE.0000000000000374.
Verhoef PA, Kannan S, Sturgill JL, Tucker EW, Morris PE, Miller AC, Sexton TR, Koyner JL, Hejal R, Brakenridge SC, Moldawer LL, Hotchkiss RS, Blood TM, Mazer MB, Bolesta S, Alexander SA, Armaignac DL, Shein SL, Jones C, Hoemann CD, Doctor A, Friess SH, Parker RI, Rotta AT, Remy KE. Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor. 2021 Mar;3(3):e0374.

Published In

Crit Care Explor

DOI

EISSN

2639-8028

Publication Date

March 2021

Volume

3

Issue

3

Start / End Page

e0374

Location

United States

Related Subject Headings

  • 3202 Clinical sciences