The Complex Integration of T-cell Metabolism and Immunotherapy.

Journal Article (Journal Article;Review)

Immune oncology approaches of adoptive cell therapy and immune checkpoint blockade aim to activate T cells to eliminate tumors. Normal stimulation of resting T cells induces metabolic reprogramming from catabolic and oxidative metabolism to aerobic glycolysis in effector T cells, and back to oxidative metabolism in long-lived memory cells. These metabolic reprogramming events are now appreciated to be essential aspects of T-cell function and fate. Here, we review these transitions, how they are disrupted by T-cell interactions with tumors and the tumor microenvironment, and how they can inform immune oncology to enhance T-cell function against tumors. SIGNIFICANCE: T-cell metabolism plays a central role in T-cell fate yet is altered in cancer in ways that can suppress antitumor immunity. Here, we discuss challenges and opportunities to stimulate effector T-cell metabolism and improve cancer immunotherapy.

Full Text

Duke Authors

Cited Authors

  • Madden, MZ; Rathmell, JC

Published Date

  • July 2021

Published In

Volume / Issue

  • 11 / 7

Start / End Page

  • 1636 - 1643

PubMed ID

  • 33795235

Pubmed Central ID

  • PMC8295173

Electronic International Standard Serial Number (EISSN)

  • 2159-8290

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-20-0569

Language

  • eng

Conference Location

  • United States