Interferon lambda protects the female reproductive tract against Zika virus infection.

Journal Article (Journal Article)

Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female reproductive tract (FRT) are not well characterized. Here we show that treatment of primary human vaginal and cervical epithelial cells with interferon (IFN)-α/β or IFN-λ induces host defense transcriptional signatures and inhibits ZIKV infection. We also assess the effects of IFNs on intravaginal infection of the FRT using ovariectomized mice treated with reproductive hormones. We find that mice receiving estradiol are protected against intravaginal ZIKV infection, independently of IFN-α/β or IFN-λ signaling. In contrast, mice lacking IFN-λ signaling sustain greater FRT infection when progesterone is administered. Exogenous IFN-λ treatment confers an antiviral effect when mice receive both estradiol and progesterone, but not progesterone alone. Our results identify a hormonal stage-dependent role for IFN-λ in controlling ZIKV infection in the FRT and suggest a path for minimizing sexual transmission of ZIKV in women.

Full Text

Duke Authors

Cited Authors

  • Caine, EA; Scheaffer, SM; Arora, N; Zaitsev, K; Artyomov, MN; Coyne, CB; Moley, KH; Diamond, MS

Published Date

  • January 17, 2019

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 280 -

PubMed ID

  • 30655513

Pubmed Central ID

  • PMC6336786

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-018-07993-2

Language

  • eng

Conference Location

  • England