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MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.

Publication ,  Journal Article
Cuevas, RA; Ghosh, A; Wallerath, C; Hornung, V; Coyne, CB; Sarkar, SN
Published in: J Immunol
May 1, 2016

Moloney leukemia virus 10, homolog (MOV10) is an IFN-inducible RNA helicase, associated with small RNA-induced silencing. In this article, we report that MOV10 exhibits antiviral activity, independent of its helicase function, against a number of positive- and negative-strand RNA viruses by enhancing type I IFN induction. Using a number of genome-edited knockout human cells, we show that IFN regulatory factor 3-mediated IFN induction and downstream IFN signaling through IFN receptor was necessary to inhibit virus replication by MOV10. MOV10 enhanced IFN regulatory factor 3-mediated transcription of IFN. However, this IFN induction by MOV10 was unique and independent of the known retinoic acid-inducible gene I/mitochondrial antiviral-signaling protein-mediated RNA-sensing pathway. Upon virus infection, MOV10 specifically required inhibitor of κB kinase ε, not TANK-binding kinase 1, for its antiviral activity. The important role of MOV10 in mediating antiviral signaling was further supported by the finding that viral proteases from picornavirus family specifically targeted MOV10 as a possible innate immune evasion mechanism. These results establish MOV10, an evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses that uses an retinoic acid-inducible gene I-like receptor-independent pathway to enhance IFN response.

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

May 1, 2016

Volume

196

Issue

9

Start / End Page

3877 / 3886

Location

United States

Related Subject Headings

  • Vesicular stomatitis Indiana virus
  • Signal Transduction
  • Rhabdoviridae Infections
  • Receptors, Retinoic Acid
  • RNA, Viral
  • RNA Interference
  • RNA Helicases
  • Interferon Type I
  • Interferon Regulatory Factor-3
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
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Cuevas, R. A., Ghosh, A., Wallerath, C., Hornung, V., Coyne, C. B., & Sarkar, S. N. (2016). MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. J Immunol, 196(9), 3877–3886. https://doi.org/10.4049/jimmunol.1501359
Cuevas, Rolando A., Arundhati Ghosh, Christina Wallerath, Veit Hornung, Carolyn B. Coyne, and Saumendra N. Sarkar. “MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.J Immunol 196, no. 9 (May 1, 2016): 3877–86. https://doi.org/10.4049/jimmunol.1501359.
Cuevas RA, Ghosh A, Wallerath C, Hornung V, Coyne CB, Sarkar SN. MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. J Immunol. 2016 May 1;196(9):3877–86.
Cuevas, Rolando A., et al. “MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.J Immunol, vol. 196, no. 9, May 2016, pp. 3877–86. Pubmed, doi:10.4049/jimmunol.1501359.
Cuevas RA, Ghosh A, Wallerath C, Hornung V, Coyne CB, Sarkar SN. MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. J Immunol. 2016 May 1;196(9):3877–3886.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

May 1, 2016

Volume

196

Issue

9

Start / End Page

3877 / 3886

Location

United States

Related Subject Headings

  • Vesicular stomatitis Indiana virus
  • Signal Transduction
  • Rhabdoviridae Infections
  • Receptors, Retinoic Acid
  • RNA, Viral
  • RNA Interference
  • RNA Helicases
  • Interferon Type I
  • Interferon Regulatory Factor-3
  • Immunology