Type III Interferons in Antiviral Defenses at Barrier Surfaces.

Journal Article (Journal Article;Review)

Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of interferons (IFNs), which induce a strong antiviral state following receptor binding. However, whereas type I IFNs control infection systemically, type III IFNs (IFN-λs) control infection locally at barrier surfaces and are often preferentially induced by these cells. In this review we focus on the role of IFN-λ at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections.

Full Text

Duke Authors

Cited Authors

  • Wells, AI; Coyne, CB

Published Date

  • October 2018

Published In

Volume / Issue

  • 39 / 10

Start / End Page

  • 848 - 858

PubMed ID

  • 30219309

Pubmed Central ID

  • PMC6179363

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

Digital Object Identifier (DOI)

  • 10.1016/j.it.2018.08.008


  • eng

Conference Location

  • England