Microbial Vertical Transmission during Human Pregnancy.

Journal Article (Journal Article;Review)

Congenital infections with pathogens such as Zika virus, Toxoplasma gondii, Listeria monocytogenes, Treponema pallidium, parvovirus, HIV, varicella zoster virus, Rubella, Cytomegalovirus, and Herpesviruses are a major cause of morbidity and mortality worldwide. Despite the devastating impact of microbial infections on the developing fetus, relatively little is known about how pathogens associated with congenital disease breach the placental barrier to transit vertically during human pregnancy. In this Review, we focus on transplacental transmission of pathogens during human gestation. We introduce the structure of the human placenta and describe the innate mechanisms by which the placenta restricts microbial access to the intrauterine compartment. Based on current knowledge, we also discuss the potential pathways employed by microorganisms to overcome the placental barrier and prospects for the future.

Full Text

Duke Authors

Cited Authors

  • Arora, N; Sadovsky, Y; Dermody, TS; Coyne, CB

Published Date

  • May 10, 2017

Published In

Volume / Issue

  • 21 / 5

Start / End Page

  • 561 - 567

PubMed ID

  • 28494237

Pubmed Central ID

  • PMC6148370

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2017.04.007

Language

  • eng

Conference Location

  • United States